MTLNOVEL I can see the status bar
Chapter 260 Orphan Drugs
Chapter 260 Orphan Drugs
Facts have proved that this kind of man who is extremely cruel to himself is really ruthless from the beginning to the end.Although the epidural anesthesia has been completed, it is still difficult to stop the bleeding of an unconscious patient-the other party is really not very cooperative with the anesthesia.
The cystoscope entered the bladder through the ruptured urethra that completed the hemostasis. Through the screen, Dr. Cao saw a group of metallic strips.Because of difficulty urinating, the patient's bladder was very full, and probably because of the prolonged filling, the necklace formed a large ball in the patient's bladder.It is absolutely impossible to pull it out directly, and it is absolutely impossible physically.
Dr. Cao sighed, and began to operate the endoscope to play a puzzle game - what is the relationship between this metal chain and the other end of the metal chain?
As time went by bit by bit, epidural anesthesia is what people often call spinal anesthesia, and the anesthesia process has no effect on the patient's consciousness.And this patient whose mental state has not been very stable began to show some irritability.Fortunately, the nurses and Dr. Cao continued to comfort him. Although the patient was restless, he was still able to lie still on the bed.
"It's almost there." In 48 minutes, Dr. Cao Xin finally untied the balled necklace, and then slowly pulled it out from the patient's bladder.
·
·
·
"Then you didn't even watch the subsequent surgery, and you just came to complain to me?" Sun Lien asked with a smile, "Is disconnection and reconnection at least a third-level operation? Isn't it good to watch it?"
"I gave up the opportunity to be the first assistant to my younger brother." Dr. Cao said with a smile, "Anyway, I did the cystoscopy, so it would be nice to have my younger brother on stage."
"I took a lot of patients today, but God bless, none of them are serious." Sun Lien sighed, pointing to the stack of outpatient certificates on his desk, "The most serious one is the big leaf that I told you just now. Acute pneumonia, transferred to the respiratory department."
"Are there still beds in the respiratory department?" The doctors in the hospital chatted, and the most common topic was whether there were still beds in certain departments. "Respiratory diseases are high in winter, can they still spare beds?"
Speaking of this question, Sun Lien also felt a little toothache. "There is no place... I can only arrange the patient to the observation room of the emergency department first." The Department of Respiratory Medicine also felt that this patient should be admitted to the hospital for treatment. After all, although the patient is young, he has a long-term smoking history.And because the amount of rust sputum is relatively large, dilated neck veins can already be observed.
While not quite to the point of respiratory distress syndrome, the situation is still not to be underestimated.But the Department of Respiratory Medicine really couldn't spare any beds—let alone the wards in the inpatient department, there was even a patient lying on the bed in the treatment room.Extra beds are not allowed in the corridors of the inpatient departments of medical units above the second level, and patients must be diverted to lower-level hospitals as much as possible.But now none of these patients can meet the discharge criteria.And this new patient was on the number of the emergency department - the emergency department cannot refuse admission.
"Then you will have to worry a lot more." Dr. Cao spread his hands to express his helplessness, "The responsibility system for the first visit. If this patient has not been transferred to the respiratory department for a day, you have to be responsible to the end."
After chatting for a while, Dr. Cao suddenly received a call.
"Ah?" He was stunned for a while, then stood up abruptly from his seat, "Have you contacted the Pharmacy Department?"
Sun Li'en sensed something was wrong from Dr. Cao's violent action.He also stood up, frowning.
"Understood, I'll ask right away." Dr. Cao sighed, hung up the phone and started sending WeChat messages.
"Brother Cao, what's the matter?" Sun Lien asked curiously, "Is there anything I can help you with?"
"Damn it..." Dr. Cao Xin, who has always been calm, scolded, "The patient I had surgery on had malignant hyperthermia!"
Sun Lien looked blank, "What?"
·
·
·
Malignant hyperthermia is a very serious genetic disease.It is also the only serious disease known to cause death from conventional anesthetics.
As a subclinical disease, malignant hyperthermia will not have any signs or symptoms before the onset.These patients have defective calcium ion channels in the cell membrane of skeletal muscle. When exposed to volatile inhaled anesthetics or depolarizing muscle relaxants, it can cause an abnormal increase in the release of calcium ions. Only at this time, malignant hyperthermia will suddenly burst out.
In patients with malignant hyperthermia, the whole body's skeletal muscles will begin to contract tonicly.The skeletal muscle contraction of the whole body bursts out huge energy, prompting the patient's body temperature to rise uncontrollably and rapidly, and causing the patient to be in a high metabolic state.
The patient's body temperature will rise rapidly to about 45°C to 46°C, and hypercapnia will occur in a high metabolic state.Accompanied by tachycardia and a sharp rise in blood pressure, profuse sweating, increased blood potassium and other symptoms.
In other words, the body at this time intends to burn itself to death.
The trouble is that general clinical cooling methods are difficult to achieve sufficient effect on malignant hyperthermia, and eventually the patient will die due to organ failure.
Since it is an idiopathic disease in the anesthesiology department, Sun Lien basically has no understanding of it.Meanwhile, Brother Cao quickly explained to Sun Lien what the situation was while sending messages for help in the communication groups of doctors in major hospitals.
"The special drug for treating malignant hyperthermia is called Danqu Lorraine." Cao Xin didn't even have time to wipe off his sweat, he was still typing quickly. "The problem is that not only our hospital doesn't have this medicine, but the hospitals in the province probably don't have it either."
Dantrolene is a specific drug for malignant hyperthermia.But there is no introduction, no production, or even a batch number in China.
Even if you go through the green channel and buy dantrolene from abroad, it will take at least two to three years for a single drug to pass the inspection and enter the customs.The shelf life of dantrolene is only three years.After the drug is successfully imported, it expires and is useless, which also leads to no reserve plan for dantrolene in domestic hospitals.
As for the domestic imitation of the road is even more long and difficult.After all, a total of 15 cases of malignant hyperthermia were reported in 16 to [-] years.Investing a lot of money in imitation may face the embarrassing situation that the cost cannot be recovered at all.As a profit-seeking enterprise, pharmaceutical companies will certainly not touch this hot yam.
Sun Li'en thought for a while, and suddenly remembered that Takeda Pharmaceutical was planning to acquire Shire Pharmaceuticals—isn't Shire Pharmaceuticals a company specializing in the production of orphan drugs?Or... Can you call Xiao Linfeng for help?
Without further ado, hit now.
However, Sun Lien did not know that the two companies capable of producing dantrolene were both American companies.
·
·
·
"President..." Xiao Linfeng's secretary quietly walked into the room, whispering something next to Xiao Linfeng's ear.Kobayashi is sitting in the conference room of Shire Pharmaceuticals in Dublin, Ireland, and he is conducting further negotiations on the merger and acquisition transaction with senior negotiators of Shire Pharmaceuticals.This group of damned Irish people don't know what is wrong with them. Facing the $640 billion merger offer, they not only refused to agree, but they actually wanted more things in their speech-such as a seat on the board of directors of Takeda Pharmaceuticals.
After all, Xiao Linfeng is also a businessman who is used to big winds and waves, but such things as transactions can only be reached with the consent of both parties.In the unlikely event that there is a foolish brain between the two parties to the transaction, the entire transaction may be completely ruined.
Xiao Linfeng was thinking about whether to throw Sun Lien out as a trump card now.
"Dantrolene?" He frowned and asked his secretary, "Does our company have this drug?"
"No." The secretary's voice was very low, "It's an orphan drug produced by an American company."
Xiao Linfeng thought for a moment, then suddenly said, "Bring in the phone, and let the translator come in."
The secretary turned around and left the meeting room, Xiao Linfeng said to the vice president of Shire Pharmaceuticals opposite, "Mr. Listen to it with me."
Due to some system problems, this book cannot be searched by APP and webpage for the time being, and cannot be read on the webpage.Sanguan has asked the editor to confirm that the book is still safe, and it should be restored in a few days.
(End of this chapter)
Facts have proved that this kind of man who is extremely cruel to himself is really ruthless from the beginning to the end.Although the epidural anesthesia has been completed, it is still difficult to stop the bleeding of an unconscious patient-the other party is really not very cooperative with the anesthesia.
The cystoscope entered the bladder through the ruptured urethra that completed the hemostasis. Through the screen, Dr. Cao saw a group of metallic strips.Because of difficulty urinating, the patient's bladder was very full, and probably because of the prolonged filling, the necklace formed a large ball in the patient's bladder.It is absolutely impossible to pull it out directly, and it is absolutely impossible physically.
Dr. Cao sighed, and began to operate the endoscope to play a puzzle game - what is the relationship between this metal chain and the other end of the metal chain?
As time went by bit by bit, epidural anesthesia is what people often call spinal anesthesia, and the anesthesia process has no effect on the patient's consciousness.And this patient whose mental state has not been very stable began to show some irritability.Fortunately, the nurses and Dr. Cao continued to comfort him. Although the patient was restless, he was still able to lie still on the bed.
"It's almost there." In 48 minutes, Dr. Cao Xin finally untied the balled necklace, and then slowly pulled it out from the patient's bladder.
·
·
·
"Then you didn't even watch the subsequent surgery, and you just came to complain to me?" Sun Lien asked with a smile, "Is disconnection and reconnection at least a third-level operation? Isn't it good to watch it?"
"I gave up the opportunity to be the first assistant to my younger brother." Dr. Cao said with a smile, "Anyway, I did the cystoscopy, so it would be nice to have my younger brother on stage."
"I took a lot of patients today, but God bless, none of them are serious." Sun Lien sighed, pointing to the stack of outpatient certificates on his desk, "The most serious one is the big leaf that I told you just now. Acute pneumonia, transferred to the respiratory department."
"Are there still beds in the respiratory department?" The doctors in the hospital chatted, and the most common topic was whether there were still beds in certain departments. "Respiratory diseases are high in winter, can they still spare beds?"
Speaking of this question, Sun Lien also felt a little toothache. "There is no place... I can only arrange the patient to the observation room of the emergency department first." The Department of Respiratory Medicine also felt that this patient should be admitted to the hospital for treatment. After all, although the patient is young, he has a long-term smoking history.And because the amount of rust sputum is relatively large, dilated neck veins can already be observed.
While not quite to the point of respiratory distress syndrome, the situation is still not to be underestimated.But the Department of Respiratory Medicine really couldn't spare any beds—let alone the wards in the inpatient department, there was even a patient lying on the bed in the treatment room.Extra beds are not allowed in the corridors of the inpatient departments of medical units above the second level, and patients must be diverted to lower-level hospitals as much as possible.But now none of these patients can meet the discharge criteria.And this new patient was on the number of the emergency department - the emergency department cannot refuse admission.
"Then you will have to worry a lot more." Dr. Cao spread his hands to express his helplessness, "The responsibility system for the first visit. If this patient has not been transferred to the respiratory department for a day, you have to be responsible to the end."
After chatting for a while, Dr. Cao suddenly received a call.
"Ah?" He was stunned for a while, then stood up abruptly from his seat, "Have you contacted the Pharmacy Department?"
Sun Li'en sensed something was wrong from Dr. Cao's violent action.He also stood up, frowning.
"Understood, I'll ask right away." Dr. Cao sighed, hung up the phone and started sending WeChat messages.
"Brother Cao, what's the matter?" Sun Lien asked curiously, "Is there anything I can help you with?"
"Damn it..." Dr. Cao Xin, who has always been calm, scolded, "The patient I had surgery on had malignant hyperthermia!"
Sun Lien looked blank, "What?"
·
·
·
Malignant hyperthermia is a very serious genetic disease.It is also the only serious disease known to cause death from conventional anesthetics.
As a subclinical disease, malignant hyperthermia will not have any signs or symptoms before the onset.These patients have defective calcium ion channels in the cell membrane of skeletal muscle. When exposed to volatile inhaled anesthetics or depolarizing muscle relaxants, it can cause an abnormal increase in the release of calcium ions. Only at this time, malignant hyperthermia will suddenly burst out.
In patients with malignant hyperthermia, the whole body's skeletal muscles will begin to contract tonicly.The skeletal muscle contraction of the whole body bursts out huge energy, prompting the patient's body temperature to rise uncontrollably and rapidly, and causing the patient to be in a high metabolic state.
The patient's body temperature will rise rapidly to about 45°C to 46°C, and hypercapnia will occur in a high metabolic state.Accompanied by tachycardia and a sharp rise in blood pressure, profuse sweating, increased blood potassium and other symptoms.
In other words, the body at this time intends to burn itself to death.
The trouble is that general clinical cooling methods are difficult to achieve sufficient effect on malignant hyperthermia, and eventually the patient will die due to organ failure.
Since it is an idiopathic disease in the anesthesiology department, Sun Lien basically has no understanding of it.Meanwhile, Brother Cao quickly explained to Sun Lien what the situation was while sending messages for help in the communication groups of doctors in major hospitals.
"The special drug for treating malignant hyperthermia is called Danqu Lorraine." Cao Xin didn't even have time to wipe off his sweat, he was still typing quickly. "The problem is that not only our hospital doesn't have this medicine, but the hospitals in the province probably don't have it either."
Dantrolene is a specific drug for malignant hyperthermia.But there is no introduction, no production, or even a batch number in China.
Even if you go through the green channel and buy dantrolene from abroad, it will take at least two to three years for a single drug to pass the inspection and enter the customs.The shelf life of dantrolene is only three years.After the drug is successfully imported, it expires and is useless, which also leads to no reserve plan for dantrolene in domestic hospitals.
As for the domestic imitation of the road is even more long and difficult.After all, a total of 15 cases of malignant hyperthermia were reported in 16 to [-] years.Investing a lot of money in imitation may face the embarrassing situation that the cost cannot be recovered at all.As a profit-seeking enterprise, pharmaceutical companies will certainly not touch this hot yam.
Sun Li'en thought for a while, and suddenly remembered that Takeda Pharmaceutical was planning to acquire Shire Pharmaceuticals—isn't Shire Pharmaceuticals a company specializing in the production of orphan drugs?Or... Can you call Xiao Linfeng for help?
Without further ado, hit now.
However, Sun Lien did not know that the two companies capable of producing dantrolene were both American companies.
·
·
·
"President..." Xiao Linfeng's secretary quietly walked into the room, whispering something next to Xiao Linfeng's ear.Kobayashi is sitting in the conference room of Shire Pharmaceuticals in Dublin, Ireland, and he is conducting further negotiations on the merger and acquisition transaction with senior negotiators of Shire Pharmaceuticals.This group of damned Irish people don't know what is wrong with them. Facing the $640 billion merger offer, they not only refused to agree, but they actually wanted more things in their speech-such as a seat on the board of directors of Takeda Pharmaceuticals.
After all, Xiao Linfeng is also a businessman who is used to big winds and waves, but such things as transactions can only be reached with the consent of both parties.In the unlikely event that there is a foolish brain between the two parties to the transaction, the entire transaction may be completely ruined.
Xiao Linfeng was thinking about whether to throw Sun Lien out as a trump card now.
"Dantrolene?" He frowned and asked his secretary, "Does our company have this drug?"
"No." The secretary's voice was very low, "It's an orphan drug produced by an American company."
Xiao Linfeng thought for a moment, then suddenly said, "Bring in the phone, and let the translator come in."
The secretary turned around and left the meeting room, Xiao Linfeng said to the vice president of Shire Pharmaceuticals opposite, "Mr. Listen to it with me."
Due to some system problems, this book cannot be searched by APP and webpage for the time being, and cannot be read on the webpage.Sanguan has asked the editor to confirm that the book is still safe, and it should be restored in a few days.
(End of this chapter)
Tip: You can use left, right, A and D keyboard keys to browse between chapters.